Study M138

Study name

Ogawa S 2015

Title

Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder

Overall design

In the search for a biomarker for major depressive disorder (MDD), high-performance liquid chromatography was used to measure amino acids and related molecules in the cerebrospinal fluid (CSF) of 52 patients with MDD (42 depressed and 10 remitted; DSM-IV) and 54 matched controls. Amino acids and related molecules were also measured using CE-TOFMS for a subset of the subjects, including 24 depressed (MDD group), 3 remitted patients, and 27 controls (control group).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

51

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Platform

MS-based; CE-MS: not reported;

PMID

25589364

DOI

10.1038/srep07796

Citation

Ogawa S, Hattori K, Sasayama D, et al. Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder. Sci Rep 2015; 5:7796.

Metabolite

Ethanolamine;