Study name | Yang P 2014b |
Title | [Study on anti-depression of Baijin capsule based on metabolomics] |
Overall design | The aim of this study was to explore the mechanism of Baijin capsule in the treatment of depression based on metabolomics. Rats modeled by chronic unpredictable mild stress were made as experimental objects. The effect of modeling and antidepressant efficacy of Baijin capsule was appraised before the study of brain metabolomics with the results of determination including the body weight, sucrose consumption and open field trial. Additionally, the study attempted to find out the biological information related to depression in samples of brain tissue based on brain metabolomics research. Pharmacokinetics research was obtained by the combined result of LC-MS/MS. Rats were divided into 4 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + SJ group (stress plus St. John's wort extract treatment at the dose of 18 mg/d), and (4) CUMS + BJ group (stress plus Baijin capsule treatment at the dose of 0.3895 g/d). The CUMS stress procedure lasted for 32 days, and drugs were administered by gastric intubation every other day for 28 days after the model building period. |
Type1; Type2; | |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose consumption test |
Sample size | 40 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC/Xevo G2 Q-TOF (Waters, USA); |
PMID | |
DOI | |
Citation | Yang P, Li X, Lin L, et al. [Study on anti-depression of Baijin capsule based on metabolomics]. World Chinese Medicine 2014;9(10):1341-5. (Article in Chinese) |
Metabolite |