Study M135

Study name

Yang P 2014b

Title

[Study on anti-depression of Baijin capsule based on metabolomics]

Overall design

The aim of this study was to explore the mechanism of Baijin capsule in the treatment of depression based on metabolomics. Rats modeled by chronic unpredictable mild stress were made as experimental objects. The effect of modeling and antidepressant efficacy of Baijin capsule was appraised before the study of brain metabolomics with the results of determination including the body weight, sucrose consumption and open field trial. Additionally, the study attempted to find out the biological information related to depression in samples of brain tissue based on brain metabolomics research. Pharmacokinetics research was obtained by the combined result of LC-MS/MS. Rats were divided into 4 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + SJ group (stress plus St. John's wort extract treatment at the dose of 18 mg/d), and (4) CUMS + BJ group (stress plus Baijin capsule treatment at the dose of 0.3895 g/d). The CUMS stress procedure lasted for 32 days, and drugs were administered by gastric intubation every other day for 28 days after the model building period.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose consumption test

Sample size

40

Tissue

Central; Brain; Brain;

Platform

MS-based; LC-MS: Waters ACQUITY UPLC/Xevo G2 Q-TOF (Waters, USA);

PMID

N/A

DOI

10.3969/j.issn.1673-7202.2014.10.026

Citation

Yang P, Li X, Lin L, et al. [Study on anti-depression of Baijin capsule based on metabolomics]. World Chinese Medicine 2014;9(10):1341-5. (Article in Chinese)

Metabolite

N-Acetyl-L-aspartic acid;

Threonic acid;

Taurine;

Inosine;