Study M133
Study name | Lu LL 2012 |
Title | [Antidepressant-like active fraction of Xiaoyaosan by metabonomics based [1H] NMR spectroscopy] |
Overall design | The aim of this study was to identify the active fraction of Xiaoyaosan in producing antidepressant effect by applying 1H NMR spectroscopy based metabonomic approach. Plasma metabolomics were analyzed. Rats were divided into 7 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + XY-A group (stress plus XY-A treatment at the dose of 0.24 g/kg), (4) CUMS + XY-B group (stress plus XY-B treatment at the dose of 0.92 g/kg), (5) CUMS + XY-C group (stress plus XY-C treatment at the dose of 0.18 g/kg), (6) CUMS + XY-D group (stress plus XY-D treatment at the dose of 0.23 g/kg), and (7) CUMS + XY-E group (stress plus XY-E treatment at the dose of 2.44 g/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were administered by gastric intubation one time each day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 42 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Varian INOVA 600 spectrometer; |
PMID | |
DOI | |
Citation | Lu L, Zhou Y, Ma Z, et al. [Antidepressant-like active fraction of Xiaoyaosan by metabonomics based [1 H] NMR spectroscopy]. Chin J Pharmacol Toxicol 2012;26(2):225-30. (Article in Chinese) |
Metabolite | 3-Hydroxybutyric acid; L-Valine; |
