Study M127
Study name | Green P 2009 |
Title | Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology |
Overall design | The Flinders Sensitive Line (FSL) rat is a genetic animal model of depression. Following recent findings that the brain fatty acid composition of FSL is characterised by increased arachidonic acid (AA), electrospray tandem mass spectrometry and 1H-NMR were used to examine lipid species in four brain regions (hypothalamus, nucleus accumbens, prefrontal cortex and striatum). The rats included 2 groups: (1) control group, (2) FSL group (the Flinders Sensitive Line rat, a unique animal model of depression). Five samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 10 |
Tissue | Central; Brain; Hypothalamus; Central; Brain; Nucleus accumbens; Central; Brain; Prefrontal cortex; Central; Brain; Striatum; |
Platform | NMR; NMR: JEOL ECA600 NMR spectrometer (JEOL UK, Welwyn, UK); MS-based; ESI-MS: triple quadrupole spectrometer (Micromass Quattro Ultima, Waters, Manchester, UK); |
PMID | |
DOI | |
Citation | Green P, Anyakoha N, Yadid G, et al. Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology. Prostaglandins Leukot Essent Fatty Acids 2009;80(4):213-20. |
Metabolite | Cholesterol; PC(32:0); PC(16:0/18:0); Total sphingolipids; PC(16:0/20:4); PC(18:1/20:4); PC(18:0/20:4); PE(18:1/20:1); PE(18:1/22:6); |
