Study M125
Study name | Liu XY 2016 |
Title | Plasma lipidomics reveals potential lipid markers of major depressive disorder |
Overall design | In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between major depressive disorder (MDD) (depressed group, n = 60) and healthy controls (control group, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 > 18 |
Sample size | 247 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Waters ACQUITY ultra performance liquid chromatography system (UPLC) (Waters Corp, Milford, USA) coupled with an AB SCIEX Triple TOF 5600 System (AB SCIEX, Framingham, USA); |
PMID | |
DOI | |
Citation | Liu X, Li J, Zheng P, et al. Plasma lipidomics reveals potential lipid markers of major depressive disorder. Anal Bioanal Chem 2016;408(23):6497-507. |
Metabolite | LysoPC(16:0); LysoPC(18:1); PC(32:1); PC(38:5); LysoPE(18:2); LysoPE(18:1); PE(34:2); PE(36:4); LysoPC(16:1/0:0); LysoPE(16:0); LysoPE(18:0); PC(32:0); PE(O-34:3); PE(O-36:5); PE(38:4); PI(38:6); PI(40:4); PI(40:6); PC(36:1); PC(40:5); PE(36:1); PE(36:3); LysoPE(20:4); PE(34:1); PE(36:2); PC(34:1); PI(36:4); PI(38:5); PI(38:4); PI(34:1); PI(36:1); PI(40:5); Free fatty acid 18:0; PC(O-40:5); PC(O-42:5); PC(O-44:5); CE(18:1); DG(34:1); DG(34:2); DG(36:1); LysoPI(18:0); PA(34:2); PC(33:1); PC(34:3); PC(38:2); PC(42:10); PI(32:1); PI(37:4); SM(36:1); SM(36:2); SM(38:1); SM(38:2); SM(40:3); SM(42:3); TG(40:0); TG(42:0); TG(42:1); TG(44:0); TG(44:1); TG(44:2); TG(46:0); TG(46:1); TG(46:2); TG(46:3); TG(47:1); TG(47:2); TG(48:0); TG(48:1); TG(48:2); TG(48:3); TG(48:4); TG(49:0); TG(49:1); TG(49:2); TG(49:3); TG(50:0); TG(50:1); TG(50:2); TG(50:3); TG(51:1); TG(51:2); TG(52:0); TG(52:1); TG(52:2); TG(52:3); TG(53:2); TG(54:0); TG(54:1); TG(54:2); TG(54:3); TG(54:4); TG(56:0); TG(56:1); TG(56:2); TG(56:3); TG(56:4); TG(56:5); TG(58:1); TG(58:3); TG(58:4); TG(58:5); TG(60:2); SM(33:1); SM(39:1); SM(41:1); SM(43:1); PE(O-36:3); PE(O-38:5); PE(O-38:6); PE(O-38:7); PE(O-40:7); PE(O-34:2); Free fatty acid 13:0; |
