Study M1142
Study name | Luo X 2023 |
Title | The changes in metabolomics profile induced by intermittent theta burst stimulation in major depressive disorder: an exploratory study |
Overall design | The aim of this study was to investigate the relationship between the mechanisms of intermittent theta burst stimulation and metabolites to elucidate its antidepressant effects in major depressive disorder (MDD) patients via targeted high-throughput profiling of metabolites. Eleven participants with MDD received 10 days intermittent theta burst stimulation treatment (MDD group). The intermittent theta burst stimulation treatment included a total of 20 sessions conducted over 2 weeks, administered on 5 consecutive days per week. A total of 318 metabolites or metabolite ratios in the plasma samples were quantified using targeted high-throughput metabolomics. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-17 >= 17 |
Sample size | 11 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: 1290 Infinity LC (Agilent Technologies) with QTRAP MS (6500+, Sciex); |
PMID | |
DOI | |
Citation | Luo X, Zhou Y, Yuan S, et al. The changes in metabolomics profile induced by intermittent theta burst stimulation in major depressive disorder: an exploratory study. BMC Psychiatry. 2023 Jul 29;23(1):550. |
Metabolite | Linoleic acid; L-Cystine; Indoleacetic acid; Serotonin; DOPA; 1-Methylhistidine; |
