Study M1134
Study name | Moura CA 2022 |
Title | Maternal stress during pregnancy in mice induces sex-dependent behavioral alterations in offspring along with impaired serotonin and kynurenine pathways of tryptophan metabolism |
Overall design | The aim of this study was to investigate the impact of maternal stress during the last week of gestation on the brain serotonin and kynurenine pathway of tryptophan metabolism and on anxiety- and depressive-like behaviors in the mouse offspring of both sexes at adulthood. Pregnant Swiss mice were divided into the following 2 groups: (1) control group, and (2) prenatal stress group. For prenatal stress, pregnant female mice were placed in transparent plastic cylinders and exposed to bright light three times a day for 45 min from the 14th day of pregnancy until delivery. Female, but not male, prenatally stressed offspring displayed a depressive-like phenotype. Tryptophan, serotonin, 5-hydroxyindole-3-acetic acid, kynurenine, and quinolinic acid levels in the brainstem and hippocampus were quantified using LC-MS (n =6/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; Swiss mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 12 |
Tissue | Central; Brain; Brainstem; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Moura CA, Cagni FC, Costa LRF, et al. Maternal stress during pregnancy in mice induces sex-dependent behavioral alterations in offspring along with impaired serotonin and kynurenine pathways of tryptophan metabolism. Dev Neurosci. 2022;44(6):603-614. |
Metabolite |
