Study M1130

Study name

Giatti S 2022

Title

Identification of a novel off-target of paroxetine: possible role in sexual dysfunction induced by this SSRI antidepressant drug

Overall design

The aim of this study was to assess the levels of norepinephrine and epinephrine in paroxetine-treated animals. Sprague-Dawley rats were divided into the following 2 groups: (1) control group (vehicle treatment), and (2) paroxetine group (paroxetine treatment at the dose of 10 mg/kg). Rats were orally treated for 14 days, then the levels of norepinephrine and epinephrine in adrenal glands were detected using LC-MS (n = 7 in each group).

Study Type

Type3;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Not reported

Sample size

14

Tissue

Peripheral; Adrenal gland; Adrenal gland;

Platform

MS-based; LC-MS: Liquid chromatography with API 3500 instrument (AB Sciex, USA);

PMID

N/A

DOI

10.1016/j.molstruc.2022.133690

Citation

Giatti S, Di Domizio A, Diviccaro S, et al. Identification of a novel off-target of paroxetine: possible role in sexual dysfunction induced by this SSRI antidepressant drug. Journal of Molecular Structure 2022;1268,133690.

Metabolite

Epinephrine;