Study M1120

Study name

Walther A 2023

Title

Depressive symptoms are negatively associated with hair N-arachidonoylethanolamine (anandamide) levels: a cross-lagged panel analysis of four annual assessment waves examining hair endocannabinoids and cortisol

Overall design

The aim of this study was to examine the endocannabinoid levels in the hair of patients with depressive symptoms. This study included 128 participants, including individuals without depressive symptoms (control group, Patient Health Questionnaire-9 < 10; n =78) and individuals with depressive symptoms (depressive group, Patient Health Questionnaire-9 >= 10; n = 30). The levels of endocannabinoids and glucocorticoids in the hair of participants were quantified using liquid chromatography coupled with tandem mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

Patient Health Questionnaire-9 >= 10

Sample size

128

Tissue

Peripheral; Hair; Hair;

Platform

MS-based; LC-MS: not reported;

PMID

36252885

DOI

10.1016/j.pnpbp.2022.110658

Citation

Walther A, Kirschbaum C, Wehrli S, et al. Depressive symptoms are negatively associated with hair N-arachidonoylethanolamine (anandamide) levels: a cross-lagged panel analysis of four annual assessment waves examining hair endocannabinoids and cortisol. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Mar 8;121:110658.

Metabolite

Cortisol;

Anandamide;