Study M1118
Study name | Shen W 2023 |
Title | The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice |
Overall design | The aim of this study was to investigate the alterations of venlafaxine on neurotransmitter levels in a mouse model of chronic unpredictable mild stress (CUMS)-induced depression. C57BL/6 mice were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) CUMS group, and (3) CUMS + venlafaxine group (stressor plus venlafaxine treatment at the dose of 12.5 mg/kg). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric once per day during the last 2 weeks of the model building period. The serum and hippocampus of mice were collected to extract neurotransmitters for LC-MS/MS. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 30 |
Tissue | Peripheral; Blood; Serum; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 HPLC system with Agilent 6410 triple stage quadrupole mass spectrometer (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Shen W, Tao Y, Zheng F, et al. The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice. Behav Brain Res. 2023 May 28;446:114399. |
Metabolite |
