Study M1113

Study name

Li D 2023a

Title

Gut-microbiome-expressed 3beta-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females

Overall design

The aim of this study was to verify if the serum estradiol levels in premenopausal women with depression were lower than those in non-depressed premenopausal women. A total of 91 premenopausal women with depression (depression group) and 98 premenopausal women without depression (control group) were included. Liquid chromatography-tandem mass spectrometry was used to compare serum estradiol levels between groups.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-V diagnosed depression

Sample size

189

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: Ekspert ultraLC 100-XL system with AB SCIEX 4500 QTRAP mass spectrometer (Applied Biosystems, Foster City, CA, USA);

PMID

36933555

DOI

10.1016/j.cmet.2023.02.017

Citation

Li D, Sun T, Tong Y, et al. Gut-microbiome-expressed 3beta-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females. Cell Metab. 2023 Apr 4;35(4):685-694.e5.

Metabolite

Estradiol;