Study M1110
Study name | Zhou CH 2023a |
Title | Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome |
Overall design | The aim of this study was to clarify the changes in lipid composition in the hippocampus and prefrontal cortex in mice treated with a single i.p. injection of (S)-ketamine after 3 weeks of chronic variable stress (CVS) exposure. C57BL/6 mice were divided into the following 3 groups: (1) control group (non-stress with saline treatment, n =10), (2) CVS group (stress with saline treatment, n =10), and (3) CVS + ketamine group (stress with ketamine treatment at a single dose of 10 mg/kg (S)-ketamine once; n =11). Changes in the lipid compositions of the hippocampus and prefrontal cortex were analyzed with a mass spectrometry-based lipidomic approach. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 31 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: ultra-HPLC with Q Exactive plus mass spectrometer (Thermo Fisher Scientific, Waltham, USA); |
PMID | |
DOI | |
Citation | Zhou C, Zhao X, Ma X, et al. Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome. Front Cell Neurosci. 2023 Feb 15;17:1114914. |
Metabolite |
