Study M1104

Study name

Zeng Z 2023

Title

GluCEST imaging and structural alterations of the bilateral hippocampus in first-episode and early-onset major depression disorder

Overall design

The aim of this study was to investigate the GluCEST changes in hippocampus in major depression disorder (MDD) and the relationship between glutamate and hippocampal subregional volumes. Thirty-two MDD patients (MDD group) and 47 healthy controls (control group) were included in this study. Proton magnetic resonance spectroscopy was used to evaluate the changes of glutamate concentrations in the hippocampus. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 14

Sample size

79

Tissue

Central; Brain; Hippocampus;

Platform

MRS; MRS: 3-T whole-body MAGNETOM Skyra system (Siemens Healthineers, Erlangen, Germany);

PMID

36808678

DOI

10.1002/jmri.28651

Citation

Zeng Z, Dong Y, Zou L, et al. GluCEST imaging and structural alterations of the bilateral hippocampus in first-episode and early-onset major depression disorder. J Magn Reson Imaging. 2023 Feb 20.

Metabolite

(Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio;