Study M1100
Study name | Wang SM 2023 |
Title | Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis |
Overall design | The aim of this study was to compare the effects of isoalantolactone and fluoxetine on depression-like behaviors in mice exposed to chronic social defeat stress (CSDS). C57BL/6 mice were divided into the following 4 groups (n = 6-8 in each group): (1) control group, (2) CSDS group, (3) CSDS + fluoxetine group (stress with fluoxetine treatment at the dose of 10 mg/kg), and (4) CSDS + isoalantolactone group (stress with isoalantolactone treatment at the dose of 10 mg/kg). The CSDS stress procedure lasted for 10 days, and drugs were administered via intragastric once per day for 5 days after stress. Short‑chain fatty acid levels in fecal samples were measured using GC-MS. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, forced swimming test, social interaction test, tail suspension test |
Sample size | 27 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: Agilent 7890B gas chromatograph; |
PMID | |
DOI | |
Citation | Wang S, Cai Q, Xu L, et al. Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis. Psychopharmacology. 2023 Jul 3. |
Metabolite |
