Study M1089
Study name | Yu ZQ 2022 |
Title | Plasma metabolic disturbances during pregnancy and postpartum in women with depression |
Overall design | The aim of this study was to investigate whether the levels of plasma metabolites was associated with postpartum depression during pregnancy and postpartum periods. Targeted paired plasma metabolomics were performed in mid-late gestational and 1-month postpartum periods in women with postpartum depression (postpartum depression group, with EPDS > 9; n = 209) or without postpartum depression (control group, with EPDS < 2; n = 222). Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Edinburgh Postnatal Depression Scale >= 9 |
Sample size | 431 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: GCMS-TQ8040 (Shimadzu, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Yu Z, Matsukawa N, Saigusa D, et al. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. iScience. 2022 Nov 24;25(12):105666. |
Metabolite |
