Study M1085
Study name | Xiang YJ 2022 |
Title | Chronic unpredictable mild stress-induced mouse ovarian insufficiency by interrupting lipid homeostasis in the ovary |
Overall design | The aim of this study was to investigate the impact of psychological stress on female reproductive function in the chronic unpredictable mild stress (CUMS) model of depression. Female C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 6 weeks. Lipid homeostasis of the ovary was detected by liquid chromatography tandem mass spectrometry analysis (n = 6 in each group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Ovary; Ovary; |
Platform | MS-based; LC-MS: ultra-performance liquid chromatography system with TripleTOF 5600 Plus high-resolution tandem mass spectrometer (SCIEX, Warrington, United Kingdom); |
PMID | |
DOI | |
Citation | Xiang Y, Jiang L, Gou J, et al. Chronic unpredictable mild stress-induced mouse ovarian insufficiency by interrupting lipid homeostasis in the ovary. Front Cell Dev Biol. 2022 Sep 8;10:933674. |
Metabolite | PS(20:2/20:2); PC(22:6/22:6); TG(8:0/8:0/10:0); LysoPC(36:3); TG(O-10:0/20:0/20:0); TG(O-20:1/16:0/18:0); Campesterol ester(28:1/22:4); CE(24:4); N-acyl ornithine(22:4/11:0); |
