Study M1079
Study name | Wang R 2023 |
Title | The effects of chronic unpredicted mild stress on maternal negative emotions and gut microbiota and metabolites in pregnant rats |
Overall design | The aim of this study was to investigate the effects of maternal experience of chronic unpredictable mild stress (CUMS) during pregnancy on the intestinal flora and its metabolites. Female Sprague-Dawley rats were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 3 weeks. On the third day of the CUMS cycle, cage mating was carried out. |
Study Type | Type1; |
Data available | |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: 8890B-5977B gas chromatography-mass spectrometer (Agilent, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Wang R, Zhao F, Li Y, et al. The effects of chronic unpredicted mild stress on maternal negative emotions and gut microbiota and metabolites in pregnant rats. PeerJ. 2023 Apr 17;11:e15113. |
Metabolite | L-Phenylalanine; Pantothenic acid; 3,4-Dihydroxymandelic acid; |
