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Study M1077

Study name

Wang F 2022

Title

Alterations in plasma lipidomic profiles in adult patients with schizophrenia and major depressive disorder

Overall design

The aim of this study was to compare plasma lipidomic profiles in adult patients with schizophrenia and major depressive disorder (MDD). In this study, lipidomic data for plasma samples from sex- and age-matched patients with MDD (MDD group, n = 35) and healthy controls (control group, n = 32) were obtained and analyzed by liquid chromatography-mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-5 diagnosed MDD, HAMD-17 >= 18

Sample size

67

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Nexera LC-30A system with Q-Exactive Plus (Thermo Fisher Scientific, San Jose, CA, USA);

PMID

36363466

DOI

10.3390/medicina58111509

Citation

Wang F, Guo L, Zhang T, et al. Alterations in plasma lipidomic profiles in adult patients with schizophrenia and major depressive disorder. Medicina. 2022 Oct 24;58(11):1509.

Metabolite

L-Acetylcarnitine;

Phosphatidylethanolamine;

Phosphatidylinositol;

PC(8:0e/6:0);

TG(18:3/18:2/18:3);

CerG2GNAc1(d38:4);

PI(16:1);

phosphatidylinositol 4,5-bisphosphate;