Study M1074

Study name

Wang CS 2023a

Title

Targeting PDK2 rescues stress-induced impaired brain energy metabolism

Overall design

The aim of this study was to identify potential differentially expressed metabolites in the serum of first-episode major depressive disorder (MDD) patients via metabolomics profiling. In this study, 41 first-episode MDD patients (MDD group) and 49 sex-matched healthy controls (control group) were selected and included. Serum samples were used for GC-MS-based metabonomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

90

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; GC-MS: not reported;

PMID

37188779

DOI

10.1038/s41380-023-02098-9

Citation

Wang C, Cui C, Xu P, et al. Targeting PDK2 rescues stress-induced impaired brain energy metabolism. Mol Psychiatry. 2023 May 15.

Metabolite

Citric acid;

Palmitic acid;

L-Phenylalanine;

L-Valine;

L-Proline;

L-Lactic acid;

L-Alanine;

Succinic acid;

L-Malic acid;