Study M1073

Study name

Wang CQ 2023

Title

Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis

Overall design

The aim of this study was to clarify the effect of BDE47 on depression in mice. C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) BDE47 exposure group. Mice in the BDE47 exposure group were administered with 25 mg/kg dose of BDE47 by gavage every other day for 30 days. The results showed that BDE47 exposure increased depression-like behaviors in mice. Then intestinal contents were used for metabolomic analyses (n = 3 in each group).

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Other animal model; Other animal model;

Criteria for depression

Tail suspension test

Sample size

6

Tissue

Peripheral; Faece; Faece;

Platform

MS-based; LC-MS: Vanquish UHPLC system (ThermoFisher, Germany) with Orbitrap Q Exactive TM HF mass spectrometer (Thermo Fisher, Germany);

PMID

37224780

DOI

10.1016/j.ecoenv.2023.115041

Citation

Wang CQ, Su Z, Dai CG, et al. Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis. Ecotoxicol Environ Saf. 2023 Jul 1;259:115041.

Metabolite

Glycoursodeoxycholic acid;

Lithocholic acid;

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0);

Eicosapentaenoic acid ethyl ester;

12S-hydroxy-5E,8Z,10Z,14Z-eicosatetraenoic acid;

N-Acetyl-DL-glutamic acid;

Methyl EudesMate;

2,5-dimethyl-N-(2-oxo-3-azepanyl)-3-thiophenesulfonamide;

Cuminaldehyde;

2,4-Dimethylbenzaldehyde;

Prostaglandin E2-1-glycerylester;

2-[4-(tert-butyl)-2,3-dihydro-1,3-thiazol2-yliden]-3-0xobutanenitrile;

15-0xoEDE;

19(R)-hydroxy Prostaglandin E2;

Monobutylphthalate;

Cyclic ADP-ribose;