Study M1069
Study name | Miao GH 2023 |
Title | Plasma lipidomic profile of depressive symptoms: a longitudinal study in a large sample of community-dwelling American Indians in the strong heart study |
Overall design | The aim of this study was to identify individual lipid species associated with risk of depression in a large sample of community-dwelling American Indians. Current depressive symptoms were assessed using the 20-item Center for Epidemiologic Studies for Depressive symptoms Scale (CES-D). Individuals with an increased risk for depression were defined as those with total CES-D score >=16. Among these participants, 537 were with depression (depression group) and 1385 were free of depression (control group) at baseline. Lipidomic profiling of fasting plasma samples from 1978 American Indians were performed. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | CES-D score >=16 |
Sample size | 1922 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Miao G, Deen J, Struzeski JB, et al. Plasma lipidomic profile of depressive symptoms: a longitudinal study in a large sample of community-dwelling American Indians in the strong heart study. Mol Psychiatry. 2023 Jan 19. |
Metabolite | LysoPC(18:1); SM(d33:1); SM(d43:1); Ceramide(d42:2); Fatty acid(8:0); PE(18:0/22:4); Carnitine C11:1; PC(p-18:2/17:0)/PC(o-18:3/17:0); GlcCer(d41:1); SM(d39:1); |
