Study M1065
Study name | Li XB 2022 |
Title | Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients |
Overall design | The aim of this study was to examine the role played by intestinal flora, metabolites, and differentially expressed genes in the occurrence and development of post-stroke depression. Healthy controls (n = 30, control group), stroke patients (n = 34, stroke group), and post-stroke depression patients (n = 26, post-stroke depression group) were included. Patients with HAMD scored between 7 and 17 (mild depression) was recruited in the post-stroke depression group. Untargeted metabolomics of the plasma samples was conducted using LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | HAMD score between 7 and 17 |
Sample size | 90 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: ultra-high-performance liquid chromatograph (1290 Infinity LC, Agilent Technologies) with quadrupole time-of-flight instrument (AB Sciex TripleTOF 6,600); |
PMID | |
DOI | |
Citation | Li X, Han G, Zhao J, et al. Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients. Front Mol Biosci. 2022 Nov 30;9:865788. |
Metabolite |
