Study M1062
Study name | Lu XD 2023 |
Title | Biochemical metabolism in the anterior cingulate cortex and cognitive function in major depressive disorder with or without insomnia syndrome |
Overall design | The aim of this study was to explore the effects of insomnia symptoms in patients with major depressive disorder (MDD) by comparing cognitive function indices among those with insomnia symptoms, those without insomnia symptoms, and healthy controls. MDD patients with insomnia symptoms (MDD with insomnia symptoms group; n =55), MDD without insomnia symptoms (MDD without insomnia symptoms group; n =39), and demographically matched healthy controls (control group; n =47) underwent proton magnetic resonance spectroscopy. The ratio of N-acetyl-aspartate/creatinine-phosphocreatine and choline-containing compounds/creatinine-phosphocreatine in bilateral anterior cingulate cortex was used to analyze brain biochemical changes. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-24 >= 20 |
Sample size | 141 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3.0 T GE MR system (Discovery MR 750 System, GE Healthcare, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Lu X, Lai S, Luo A, et al. Biochemical metabolism in the anterior cingulate cortex and cognitive function in major depressive disorder with or without insomnia syndrome. J Affect Disord. 2023 Aug 15;335:256-263. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
