Study M1061
Study name | Li YB 2023 |
Title | Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression |
Overall design | The aim of this study was to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model. Sprague-Dawley rats were divided into the following 2 groups (n = 20 in each group): (1) control group, and (2) CUMS group. Animals were sacrificed after either 4 weeks or 8 weeks under CUMS to mimic long-term depression in humans. A UHPLC-MS-based metabolomic method was used to investigate the characteristics of fecal metabolism in depression rats. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 40 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Acquity UHPLC system (Acquity LC, Waters) with QE HFX mass spectrometer; |
PMID | |
DOI | |
Citation | Li Y, Li J, Cheng R, et al. Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression. Front Cell Infect Microbiol. 2023 Mar 27;13:1116277. |
Metabolite | L-Alanine; Succinic acid; Histamine; Thiamine monophosphate; 3-(3-Hydroxyphenyl)propanoic acid; D-Arabitol; Dimethyl sulfone; Gentisic acid; PE(39:6); L-Gulonolactone; 1,2-Dimethylimidazole; D-Pinitol; Pro-leu; Ingenol; |
