Study M1060
Study name | Li W 2022 |
Title | Chaihu-Shugan-San ameliorates tumor growth in prostate cancer promoted by depression via modulating sphingolipid and glycerinphospholipid metabolism |
Overall design | The aim of this study was to evaluate the effects of Chaihu-Shugan-San on stress-accelerated prostate cancer in a BALB/C nude mice model. For prostate cancer model, 10^6 PC-3 tumor cells were subcutaneously injected into the flank of the BALB/c nude mice. For stress, chronic unpredictable mild stress (CUMS) was used as depression model. BALB/c nude mice were divided into the following 3 groups (n = 6 in each group): (1) tumor-bearing group (tumor-bearing mice, without stress), (2) CUMS + tumor-bearing group (tumor-bearing mice, with stress), and (3) CUMS + tumor-bearing + Chaihu-Shugan-San group (tumor-bearing mice, with stress and Chaihu-Shugan-San treatment at the dose of 9.6 g/kg). The CUMS mice were restrained for 3 weeks before tumor transplantation, and continued to be restrained daily for 6 weeks. Chaihu-Shugan-San was administrated via intragastric once per day for 6 weeks started at the time of inoculating PC-3 cells. Serum samples were used for LC-MS lipidomics analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; BALB/c nude mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, tail suspension test |
Sample size | 18 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Li W, Zhou R, Zheng J, et al. Chaihu-Shugan-San ameliorates tumor growth in prostate cancer promoted by depression via modulating sphingolipid and glycerinphospholipid metabolism. Front Pharmacol. 2022 Dec 5;13:1011450. |
Metabolite | Cer(d18:1/24:0); PC(16:0/18:2); PE(18:0/18:2); PC(18:0/20:4); PC(18:0/18:2); PC(18:0/18:1); PC(18:1/18:2); PI(18:1/20:4); PI(18:1/18:2); PI(16:0/18:2); SM(d42:1)+H; PC(18:0/22:6); PI(16:0/22:6); PE(18:0e/18:2); PC(16:0/20:5); PC(18:2/18:2); PC(18:3e/20:0); PC(33:2e); PC(19:0/18:2); PC(20:2e/20:5); PC(20:2e/20:4); Hex1Cer(d18:1/24:0); Cer(m41:1+O); PE(18:1e/22:6); |
