Study M106

Study name

Hashimoto K 2017

Title

Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study

Overall design

In this study, metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (depressed group, n = 28) with major depressive disorder (MDD) and age- and gender-matched healthy controls (control group, n = 18) were performed Among these participants, MDD patients (n = 19) and comparison control subjects (n = 17) were followed for 3 years. Metabolomics analyses of CSF samples from the MDD and control groups were performed at the Chemicals Evaluation and using an GC-MS/MS based multiple reaction monitoring metabolomics platform.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Geriatric depression; Geriatric depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-21 < 16

Sample size

46

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Platform

MS-based; GC-MS: GCMS-TQ8030 (Shimadzu Co., Kyoto, Japan);

PMID

28615661

DOI

10.1038/s41598-017-03836-0

Citation

Hashimoto K, Ishima T, Sato Y, et al. Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study. Sci Rep 2017;7(1):3485.

Metabolite

Ascorbic acid;