Study M1058
Study name | Kong LM 2023 |
Title | Neurochemical and microstructural alterations in bipolar and depressive disorders: a multimodal magnetic resonance imaging study |
Overall design | The aim of this study was to compare the microstructure and neurometabolites in eight brain regions of medication-free patients with bipolar disorder and those with unipolar depression. A total of 30 patients with unipolar depression patients (depression group) and 20 matched healthy controls (control group) underwent 3.0T magnetic resonance imaging with chemical exchange saturation transfer for glutamate imaging, multivoxel magnetic resonance spectroscopy, and diffusion kurtosis imaging. Metabolite levels in eight brain regions, including anterior cingulate cortex, posterior cingulate cortex, bilateral ventral prefrontal white matter, bilateral dorsal thalamus, and bilateral basal ganglia, were reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed depression |
Sample size | 50 |
Tissue | Central; Brain; Dorsal thalamus; Central; Brain; Anterior cingulate cortex; Central; Brain; Posterior cingulate cortex; Central; Brain; Ventral prefrontal white matter; Central; Brain; Basal ganglia; |
Platform | MRS; MRS: 3.0T GE MRI system (Signa, General Electric Medical System, USA); |
PMID | |
DOI | |
Citation | Kong L, Li H, Lin F, et al. Neurochemical and microstructural alterations in bipolar and depressive disorders: a multimodal magnetic resonance imaging study. Front Neurol. 2023 Mar 1;14:1089067. |
Metabolite |
