Study M1055

Study name

Kasuya K 2023

Title

Relationship between urinary metabolomic profiles and depressive episode in Antarctica

Overall design

The aim of this study was to elucidate the urinary metabolite biomarkers that have potential to discriminate subjects with depressive episodes from those without these symptoms. Thirty participants stayed in Antarctica for 12 months were enrolled in the study. Five participants showed major depressive episodes (Patient Health Questionnaire-9 score >= 10; depression group) at 12 months. The remaining 25 participants were included in the non-depressive episode group (control group). The urinary metabolites between two groups were compared at 12 months using LC-MS-based metabolomic analysis.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

Patient Health Questionnaire-9 >= 10

Sample size

30

Tissue

Peripheral; Urine; Urine;

Platform

MS-based; LC-MS: Agilent Technologies 1290 Infinity instrument (Santa Clara, CA, USA) with Agilent Technologies G6230B TOF mass spectrometer;

PMID

36674456

DOI

10.3390/ijms24020943

Citation

Kasuya K, Imura S, Ishikawa T, et al. Relationship between urinary metabolomic profiles and depressive episode in Antarctica. Int J Mol Sci. 2023 Jan 4;24(2):943.

Metabolite

Beta-Alanine;

Ornithine;

Cytosine;

L-Cystathionine;

L-Alpha-aminobutyric acid;

Carnosine;

3-Methylhistidine;

Pyridoxamine;

N-acetylhistamine;

4-Guanidinobutanoic acid;

2-Aminoadipic acid;