Study M1050

Study name

Huang XS 2023

Title

Cognitive dysfunction and neurometabolic alternations in major depressive disorder with gastrointestinal symptoms

Overall design

The aim of this study was to explore the alterations of neurometabolism in patients with major depressive disorder (MDD) and gastrointestinal symptoms. Fifty MDD patients with gastrointestinal symptoms (MDD with gastrointestinal symptoms group), 46 patients without gastrointestinal symptoms (MDD without gastrointestinal symptoms group) and 50 demographically matched healthy controls (control group) were included in this study. Proton magnetic resonance spectroscopy was used to obtain ratios of N-acetyl aspartate to creatine and choline-containing compounds to creatine in the thalamus, putamen and anterior cingulate cortex.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-5 diagnosed MDD, HAMD-24 >= 20

Sample size

146

Tissue

Central; Brain; Thalamus;

Central; Brain; Putamen;

Central; Brain; Anterior cingulate cortex;

Platform

MRS; MRS: Discovery MR 750 3.0 T MRI scanner (General Electric, Milwaukee, WI, USA);

PMID

36372125

DOI

10.1016/j.jad.2022.10.036

Citation

Huang X, Lai S, Lu X, et al. Cognitive dysfunction and neurometabolic alternations in major depressive disorder with gastrointestinal symptoms. J Affect Disord. 2023 Feb 1;322:180-186.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;