Study M105
Study name | Goto T 2017 |
Title | Effects of diet quality and psychosocial stress on the metabolic profiles of mice |
Overall design | In this study, the authors hypothesized that there are some key peripheral metabolites to change stress-susceptible behavior. GC-MS metabolomics of plasma, liver, and cecal content were performed. Mice were divided into 4 groups: (1) control group (standard laboratory diet: nonpurified diet, n = 8), (2) sCSDS group (subchronic mild social defeat stress stress plus standard laboratory diet: nonpurified diet, n = 6), (3) AIN diet group (semipurified pellet diet, n = 8), (4) sCSDS + AIN diet group (subchronic mild social defeat stress stress plus AIN-93G diet group n = 7). Mice were fed their specified diet throughout the habituation and experimental periods: from the time of their arrival in the animal facility (Day -6) to the time of tissue sampling (Day 12). The sCSDS experiment was carried out on 10 consecutive days (Day 1 to Day 10). Metabolites with social stress-induced changes were identified by comparing sCSDS group and control group, and sCSDS + AIN diet group and AIN diet group. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6JJmsSlc mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test |
Sample size | 29 |
Tissue | Peripheral; Faece; Faece; Peripheral; Blood; Plasma; Peripheral; Liver; Liver; |
Platform | MS-based; GC-MS: GCMS-QP2010 Ultra (Shimadzu, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Goto T, Tomonaga S, Toyoda A. Effects of diet quality and psychosocial stress on the metabolic profiles of mice. J Proteome Res 2017;16(5):1857-67. |
Metabolite | Glycerol; L-Lactic acid; L-Asparagine; |
