Study M1047

Study name

Qu YG 2023

Title

Repeated use of 3,4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: a role of gut-microbiota-brain axis

Overall design

The aim of this study was to examine whether repeated administration of 3,4-methylenedioxymethamphetamine can affect resilience versus susceptibility in mice exposed to chronic social defeat stress (CSDS). C57BL/6 mice were divided into the following 3 groups: (1) control group (n = 10), (2) CSDS group (stressor plus saline treatment; n = 9), and (3) CSDS + 3,4-methylenedioxymethamphetamine group (stressor plus 3,4-methylenedioxymethamphetamine treatment; n = 7). Saline or 3,4-methylenedioxymethamphetamine (10 mg/kg/day) was administered intraperitoneally to mice for 14 days. Subsequently, CSDS was carried out for 10 days. 3,4-Methylenedioxymethamphetamine-treated mice show stress resilience exposed to CSDS. Plasm samples were used for untargeted metabonomic analysis.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Social defeat model; Social defeat model;

Criteria for depression

Sucrose preference test

Sample size

26

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: not reported;

PMID

36571897

DOI

10.1016/j.psychres.2022.115020

Citation

Qu Y, Eguchi A, Wan X, et al. Repeated use of 3,4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: a role of gut-microbiota-brain axis. Psychiatry Res. 2023 Feb;320:115020.

Metabolite

Imidazoleacetic acid;

Ureidopropionic acid;

Phenyllactic acid;

Lactose;

3-Hydroxymethylglutaric acid;

Galactinol;

LysoPE(18:0/0:0);

Allose;

PC(16:0/0:0);

N(6)-Methyllysine;

5-Keto-D-gluconate;

Cysteineglutathione disulfide;

Benzophenone;