Study M1043
Study name | Liu MX 2023 |
Title | Simultaneous measurement of amino acid enantiomers in the serum of late-life depression patients using convenient LC-MS/MS method with Na-(5-fluoro-2,4-dinitrophenyl)-l-leucinamide derivatization |
Overall design | In this study, a convenient LC-MS/MS method was established for enantioseparation and quantification of multiple amino acids in human serum. Blood samples of non-depressed controls (control group, n = 35) and late-life depression patients (late-life depression group, n = 40) were obtained. The LC-MS/MS method was used to determine the enantiomer specific amino acid profiles in serum samples from these late-life depression patients and nondepressed controls. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | Not reported |
Sample size | 75 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: UltiMate 3000 HPLC system with API 4000 MS/MS system; |
PMID | |
DOI | |
Citation | Liu M, He J, Ruan C, et al. Simultaneous measurement of amino acid enantiomers in the serum of late-life depression patients using convenient LC-MS/MS method with Na-(5-fluoro-2,4-dinitrophenyl)-l-leucinamide derivatization. J Pharm Biomed Anal. 2023 Jun 15;230:115387. |
Metabolite |
