Study M1037
Study name | Danyeli LV 2023 |
Title | Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine |
Overall design | The aim of this study was to explore the association of baseline functional and metabolic measures with the magnitude of delayed S-ketamine-induced changes. Thirty-five healthy male participants underwent 7 T magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging before, during, and 24 h after a single S-ketamine or placebo infusion. Changes in glutamatergic measures in the pregenual anterior cingulate cortex were examined. The glutamate and glutamine concentration levels were reported in institutional units. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 35 |
Tissue | Central; Brain; Pregenual anterior cingulate cortex; |
Platform | MRS; MRS: ultra-high field 7 T scanner (Siemens Healthineers, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Danyeli LV, Sen ZD, Colic L, et al. Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine. Transl Psychiatry. 2023 Feb 16;13(1):60. |
Metabolite |
