Study M1031

Study name

Chappell K 2022

Title

The ERICH3 rs11580409 polymorphism is associated with 6-month antidepressant response in depressed patients

Overall design

The aim of this study was to analyze the association of the ERICH3 rs11580409 genetic polymorphism with response following antidepressant treatment and plasma serotonin levels in METADAP, a cohort of 6-month antidepressant-treated depressed patients. Clinical (n = 377) and metabolic (n = 150) data were obtained at baseline and after 3 and 6 months of treatment in depressed patients. Plasma serotonin levels were determined using UPLC-MS.

Study Type

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR diagnosed MDD, HAMD-17 >= 18

Sample size

150

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Waters Acquity UPLC system with Thermo Scientifc Q Exactive mass spectrometer;

PMID

35878676

DOI

10.1016/j.pnpbp.2022.110608

Citation

Chappell K, Colle R, Ait Tayeb AEK, et al. The ERICH3 rs11580409 polymorphism is associated with 6-month antidepressant response in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Dec 20;119:110608.

Metabolite

Serotonin;