Study M1028

Study name

Ali-Sisto T 2023

Title

Serum levels of carnosine may be associated with the duration of MDD episodes

Overall design

The aim of this study was to explore the possible role of carnosine and histidine in major depressive disorder (MDD). The study comprised 99 MDD patients (MDD group) and 253 non-depressed controls (control group). Fasting serum samples were analyzed using ultra-performance liquid chromatography coupled to mass spectrometry to determine the serum levels of carnosine and histidine.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

352

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: ACQUITY UPLCMS/MS system (Waters Corporation, Milford, MA, USA);

PMID

36208690

DOI

10.1016/j.jad.2022.09.092

Citation

Ali-Sisto T, Tolmunen T, Kraav SL, et al. Serum levels of carnosine may be associated with the duration of MDD episodes. J Affect Disord. 2023 Jan 1;320:647-655.

Metabolite

Carnosine;