Study M1023
Study name | Duan JJ 2022 |
Title | Viral metagenomics combined with metabolomics reveals the role of gut viruses in mouse model of depression |
Overall design | The aim of this study was to evaluate the alterations of gut virome and neurotransmitters in chronic restraint stress (CRS)-induced mouse model of depression based on viral metagenomics and LC-MS/MS metabolomics analyses. C57BL/6 J mice were divided into the following 2 groups: (1) control group, and (2) CRS group. CRS group mice were subjected to the chronic restraint stress protocol for 21 days, 6 h per day. Metabolites profile of neurotransmitters from fecal samples were analyzed by LC-MS/MS (n = 6-8/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 14 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: UPLC (ExionLC AD) with QTRAP 6,500+ System; |
PMID | |
DOI | |
Citation | Duan J, Wang W, Jiang T, et al. Viral metagenomics combined with metabolomics reveals the role of gut viruses in mouse model of depression. Front Microbiol. 2022 Nov 15;13:1046894. |
Metabolite | L-Phenylalanine; L-Leucine; L-Serine; L-Methionine; L-Aspartic acid; L-Tyrosine; Phenylpyruvic acid; |
