Study M1021

Study name

Ait Tayeb AEK 2023

Title

Metabolomic profiles of 38 acylcarnitines in major depressive episodes before and after treatment

Overall design

The aims of the current study were to compare the plasma levels of 38 acylcarnitines in patients with a current major depressive episode and healthy controls, and to assess their changes after antidepressant treatment. Metabolomic profiles of 38 plasma short-, medium-, and long-chain acylcarnitines were performed by liquid chromatography-mass spectrometry in 893 healthy controls (control group) and 460 depressed patients (depression group) before and after 6 months of antidepressant treatment.

Study Type

Type1;

Type2;

Type4;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR-diagnosed major depressive disorder, HAMD-17 >= 18

Sample size

1353

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: ACQUITY UPLC I Class system (Waters Corporation, Milford, MA, USA) with API 4000 Q-TRAP mass spectrometer (AB Sciex, Darmstadt, Germany);

PMID

37226550

DOI

10.1017/S003329172300140X

Citation

Ait Tayeb AEK, Colle R, Chappell K, et al. Metabolomic profiles of 38 acylcarnitines in major depressive episodes before and after treatment. Psychol Med. 2023 May 25:1-10.

Metabolite

Stearoylcarnitine;

Hexanoylcarnitine;

L-Octanoylcarnitine;

Decanoylcarnitine;

Dodecanoylcarnitine;

Tetradecanoylcarnitine;

L-Palmitoylcarnitine;

Glutaconylcarnitine;

Valerylcarnitine;

Hexadecenoylcarnitine;

Octadecadienylcarnitine;

Tetradecadienylcarnitine;

Hydroxytetradecenoylcarnitine;

Hydroxyhexadecenoylcarnitine;

Tetradecenoylcarnitine;

Propenoylcarnitine;

Butenylcarnitine;

Hexenoylcarnitine;

O-Pimeloylcarnitine;

Hydroxytetradecadienylcarnitine;

Hydroxyhexadecanoylcarnitine;

Hexadecadienylcarnitine;

Nonaylcarnitine;