Study M1016
Study name | Shao JJ 2023 |
Title | Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors |
Overall design | The aim of this study was to explore the potential anti-depressant effects of ginsenoside Rh4 and its mechanisms of action in the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6J mice were divided into the following 4 groups: (1) control group, (2) CUMS group, (3) CUMS + ginsenoside Rh4 group (stressor plus ginsenoside Rh4 treatment at the dose of 40 mg/kg), and (4) CUMS + imipramine group (stressor plus imipramine treatment at the dose of 15 mg/kg). The CUMS stress procedure lasted for 9 weeks, and drugs were administered via intragastric during the last 6 weeks of the model building period. The short chain fatty acid content in feces was determined using GC-MS (n = 6/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Shao J, Ma X, Qu L, et al. Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors. Food Chem. 2023 Mar 15;404(Pt B):134639. |
Metabolite |
