Study M1010
Study name | Lin SS 2022 |
Title | Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach |
Overall design | The aim of this study was to investigate the underlying antidepressant mechanisms of crocetin through multi-omics in the chronic unpredictable mild stress (CUMS) model of depression. ICR mice were divided into the following 3 groups (n = 9 in each group): (1) control group, (2) CUMS group, and (3) CUMS + crocetin group (stressor plus crocetin treatment at the dose of 80 mg/kg). The CUMS stress procedure lasted for 3 weeks, and crocetin was administered via intragastric once per day during the model building period. Fecal samples were used for metabonomic analysis (n = 5/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 15 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: ExionLCTMAD system Ultra Performance Liquid Chromatography (AB Sciex, USA) with quadrupole time-of-flight mass spectrometer, Triple TOFTM5600 + (AB Sciex, USA); |
PMID | |
DOI | |
Citation | Lin S, Li Q, Xu Z, et al. Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach. Psychopharmacology (Berl). 2022 Nov;239(11):3657-3677. |
Metabolite | L-Glutamine; 5-Hydroxyindoleacetic acid; Indoleacetic acid; Indolelactic acid; Indoleacetaldehyde; Alpha-Linolenic acid; 4-Hydroxyphenylpyruvic acid; 15H-11,12-EETA; Phenol; 16(R)-HETE; Vanillin; Indole-3-carboxaldehyde; 1,3-Dihydro-(2H)-indol-2-one; Piperidine; 2-(Methylamino)benzoic acid; 2-Hydroxycinnamic acid; Indole-3-acetamide; 15d PGD2; 15(R)-15-methyl prostaglandin A2; 2,8-Quinolinediol; N-(3-Methylbut-2-EN-1-YL)-9H-purin-6-amine; Abscisic acid; Genistin; Janthitrem C; Hexadecasphingosine; 1-Acetylindole; N-Acetyl-DL-glutamic acid; 2-Hydroxy-3-(1H-imidazol-5-yl)propanoic acid; (S)-10,16-Dihydroxyhexadecanoic acid; 15(R)-Hydroxyeicosatetraenoic acid; N'-Formylkynurenine; 16,16-Dimethylprostagladin A2; 16,16-Dimethylprostaglandin A1; (5S,12R)-5,12-dihydroxyicosa-6,8,10-trienoic acid; Meteneprost; Dodecanedioic acid; 7-[3-Hydroxy-2-(3-hydroxyoctyl)-5-oxocyclopentyl]heptanoic acid; |
