Study M1006
Study name | Zhu HY 2022 |
Title | Perinatal transmission of a probiotic Bifidobacterium strain protects against early life stress-induced mood and gastrointestinal motility disorders |
Overall design | The aim of this study was to investigate whether Bifidobacterium breve CCFM1025 can prevent early life stress-induced mood and gastrointestinal motility disorders in the maternal separation model of depression. C57BL/6J mice were divided into the following 4 groups: (1) control group, (2) maternal separation group, (3) Bifidobacterium breve CCFM1025 group, and (4) maternal separation + Bifidobacterium breve CCFM1025 group. Pregnant females were assigned to control or Bifidobacterium breve CCFM1025 groups and treated with 10% skimmed milk or CCFM1025 (4 x 10^9 CFU/d) separately through oral gavage. The probiotic and vehicle administration was initiated at pregnancy and ceased at childbirth. All offspring from each group were equally divided into control or maternal separation subgroups. Offspring in the maternal separation subgroup were subjected to 3 hours of maternal separation per day until weaning. Fecal levels of short-chain fatty acids were measured by GC-MS. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Forced swimming test |
Sample size | 387 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: TSQ 9000 (Thermo Scientific); |
PMID | |
DOI | |
Citation | Zhu H, Tian P, Qian X, et al. Perinatal transmission of a probiotic Bifidobacterium strain protects against early life stress-induced mood and gastrointestinal motility disorders. Food Funct. 2022 Jul 18;13(14):7520-7528. |
Metabolite |
