Study M1001
Study name | Song LJ 2022 |
Title | Roseburia hominis alleviates neuroinflammation via short-chain fatty acids through histone deacetylase inhibition |
Overall design | The aim of this study was to explore the antineuroinflammatory effect of the potential probiotic Roseburia hominis and its underlying mechanisms in germ free rats. Germ free Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) Roseburia hominis group. Rats were treated with Roseburia hominis (2 x 10^9 CFU/day) or sterile phosphatebuffered saline by intragastric administration for 5 days. Behavioral experiments were performed 12 days after gavage. Short-chain fatty acid levels in rat serum were measured 14 days after gavage by UPLC-MS/MS (n =6/group). |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Ultimate 3000 RSLC system (Dionex Inc., Amsterdam, The Netherlands) with TSQ Quantiva Ultra triplequadrupole mass spectrometer (Thermo Fisher, Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Song L, Sun Q, Zheng H, et al. Roseburia hominis alleviates neuroinflammation via short-chain fatty acids through histone deacetylase inhibition. Mol Nutr Food Res. 2022 Sep;66(18):e2200164. |
Metabolite |
