Study M1000
Study name | Gu Y 2022 |
Title | Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor beta and the MAPK/ERK signaling pathway |
Overall design | The aim of this study was to explore whether estrogen levels affect 5-HT reuptake in the ovariectomy induced depression model. Female Sprague-Dawley rats were divided into the following 3 groups (n = 6 in each group): (1) control group (sham ovariectomy), (2) ovariectomy group (ovariectomy), and (3) ovariectomy + estradiol group (ovariectomy with estradiol treatment at the dose of 35 ug/kg). After 4 weeks of ovariectomy, estradiol treatment was administrated for 2 weeks. After 6 weeks of ovariectomy, all rats were subjected to the forced swimming test. The level of 5-HT in the prefrontal cortex was measured by LC-MS. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Gu Y, Zhang N, Zhu S, et al. Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor beta and the MAPK/ERK signaling pathway. Eur J Pharmacol. 2022 Jun 5;924:174939. |
Metabolite |
