Study M100
Study name | Akimoto H 2017 |
Title | High-resolution magic-angle spinning-1H-NMR spectroscopy-based metabolic profiling of hippocampal tissue in rats with depression-like symptoms |
Overall design | High-resolution magic-angle spinning-1H-NMR (HRMAS-1H-NMR) spectroscopy was utilized to comprehensively analyze the changes in metabolites in the hippocampal tissue of rats exposed to chronic stress via multi-step principal component analysis (multi-step PCA). Rats were divided into 2 groups (n = 6 in each group): (1) control group, (2) CS group (chronic stress). The chronic stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; |
Platform | NMR; NMR: Varian INOVA-700 NMR instrument; |
PMID | |
DOI | |
Citation | Akimoto H, Oshima S, Ohara K, et al. High-resolution magic-angle spinning-1H-NMR spectroscopy-based metabolic profiling of hippocampal tissue in rats with depression-like symptoms. Biol Pharm Bull 2017;40(6):789-96. |
Metabolite |
