Study M091
Study name | Wang W 2016 |
Title | Targeted metabolomic pathway analysis and validation revealed glutamatergic disorder in the prefrontal cortex among the chronic social defeat stress mice model of depression |
Overall design | Therefore, we conducted a liquid chromatography-tandem mass spectrometry (LC-MS/MS) detection of 25 major metabolites of tryptophanic, GABAergic, and catecholaminergic pathways in the prefrontal cortex (PFC) of mice in chronic social defeat stress (CSDS). Mice were divided into 2 groups: (1) control group (n = 15) (2) CSDS group (chronic social defeat stress group, n = 30). The CSDS group were divided into depressed group and resilient group according to the social interaction test. Ten samples per group were used for metabonomic analysis. The CSDS stress procedure lasted for 10 days. Data from depressed group and control group were used. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test. social interaction test |
Sample size | 30 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: AB Sciex Triple Quad 6500 mass spectrometry system with Waters ACQUITY UPLC chromatographic instrument control; |
PMID | |
DOI | |
Citation | Wang W, Guo H, Zhang SX, et al. Targeted metabolomic pathway analysis and validation revealed glutamatergic disorder in the prefrontal cortex among the chronic social defeat stress mice model of depression. J Proteome Res 2016;15(10):3784-92. |
Metabolite |
