Study M090
Study name | Tian JS 2016 |
Title | A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan |
Overall design | In this study, 25 depressed patients and 33 healthy volunteers were recruited. A GC-MS based metabolomics approach and the multivariate statistical methods were used for analyzing the urine metabolites of depressed patients before (depressed group) and after treatment (depressed group at 6-week treatment) compared with healthy controls (control group). Then the biomakers through metabolomics determination were carried out the quantitative analysis. 25 depressed patients took Xiaoyaosan decoction for 6 weeks. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed depression, HAMD-17 > 17 |
Sample size | 58 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Trace gas chromatograph with PolarisQ Ion Trap mass spectrometer (Thermo Fisher Scientific Inc., Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Tian JS, Peng GJ, Wu YF, et al. A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan. J Chromatogr B Analyt Technol Biomed Life Sci 2016;1026:227-35. |
Metabolite |
