Study M088
Study name | Serrano-Contreras JI 2016 |
Title | NMR-based metabonomic analysis of normal rat urine and faeces in response to (+-)-venlafaxine treatment |
Overall design | With a pharmacometabonomic approach using NMR in combination with different chemometric methods, a determination was made of subtle changes in the metabolic profile (metabotype) of urine and fasces in normal Wistar rats following a single administration of pharmacological doses of (+-)-venlafaxine hydrochloride. All the rats were divided into 3 groups (n = 18 in each group): (1) control group (single dose of vehicle 5% Tween-80 w/v), (2) low dose of venlafaxine group (22 mg/kg of b.w. of venlafaxine free base, dose volume 4 mL/kg b.w.), and (3) high dose of venlafaxine group (112 mg/kg of b.w. of venlafaxine free base, dose volume 4 mL/kg b.w.). Urine samples were collected at intervals of 0-6 h, 6-12 h and 12-24 h. The collection period of stool samples was 0-24 h. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 54 |
Tissue | Peripheral; Urine; Urine; Peripheral; Faece; Faece; |
Platform | NMR; NMR: Varian NMR system 500 spectrometer (now Agilent, Santa Clara, CA, US); |
PMID | |
DOI | |
Citation | Serrano-Contreras JI, García-Pérez I, Meléndez-Camargo ME, et al. NMR-based metabonomic analysis of normal rat urine and faeces in response to (+-)-venlafaxine treatment. J Pharm Biomed Anal 2016;123:82-92. |
Metabolite | Hippuric acid; Phenylacetylglycine; Creatinine; Acetic acid; Dimethylamine; |
