Study M080
Study name | Gupta M 2016 |
Title | TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics |
Overall design | In this study, a pharmacometabolomics-informed pharmacogenomics research strategy was used to identify genes associated with metabolites that were related to SSRI response. Plasma metabolite concentrations were assayed using samples from 306 randomly selected MDD patients at baseline and after 4 and 8 weeks of SSRI therapy using a high-performance liquid chromatography electrochemical coulometric array metabolomics platform. |
Study Type | Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 > 14 |
Sample size | 306 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LCECA: high-performance liquid chromatography electrochemical coulometric array metabolomics platform (LCECA); |
PMID | |
DOI | |
Citation | Gupta M, Neavin D, Liu D, et al. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol Psychiatry 2016;21(12):1717-25. |
Metabolite |
