Study M073

Study name

Ali-Sisto T 2016

Title

Purine metabolism is dysregulated in patients with major depressive disorder

Overall design

In order to further clarify the role of purine metabolism in major depressive disorder (MDD), the aim of the present study was to compare the serum levels of 7 metabolites relevant to purine metabolism (i.e., inosine, xanthine, guanosine, hypoxanthine, xanthosine, adenosine, and IMP) (1) between an MDD group and a non-depressed group, (2) with regards to the remission status of the MDD group, and (3) longitudinally within the remitted and non-remitted groups. The samples comprised MDD patients (depressed group, n = 99) and non-depressed controls (control group, n = 253). Fasting serum samples were analyzed using ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS) to determine seven purine cycle metabolites belonging to the purine cycle. The levels of these metabolites were investigated in the MDD patients (depressed group, n = 99) vs. non-depressed controls (control group, n = 99).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

352

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: ACQUITY UPLC-MS/MS system (Waters Corporation, Milford, MA, USA);

PMID

27153521

DOI

10.1016/j.psyneuen.2016.04.017

Citation

Ali-Sisto T, Tolmunen T, Toffol E, et al. Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology 2016;70:25-32.

Metabolite

Xanthine;

Inosine;

Adenosine;

Guanosine;