Study M067
Study name | Xu F 2015 |
Title | Macaques exhibit a naturally-occurring depression similar to humans |
Overall design | Here, we describe and model a naturally-occurring depressive state in a non-human primate species, the cynomolgus monkey (Macaca fascicularis), in a realistic social ethological context and associate the depressed behavioral phenotype with significant serum metabolic perturbations. The subjects that displayed the highest frequencies of depressive behaviors over the observational period were selected (naturally-occurring depression, n = 20), and healthy adult female subjects were selected (control group, n = 20). The serum metabolic phenotype of depressed and healthy subjects were compared using GC-MS analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Non-human primate; Cynomolgus monkey; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Behavioral observation |
Sample size | 23 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C GC-MS system (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Xu F, Wu Q, Xie L, et al. Macaques exhibit a naturally-occurring depression similar to humans. Sci Rep 2015;5:9220. |
Metabolite | myo-Inositol; Citric acid; Glycerol; L-Phenylalanine; L-Leucine; L-Proline; L-Serine; L-Threonine; L-Methionine; L-Asparagine; D-Fructose; D-Glucose; Urea; Phosphoric acid; alpha-D-Glucose; Ornithine; Aminomalonic acid; Putrescine; Aminotriethoxysilane; |
