Study M066
Study name | Wu HW 2015 |
Title | A 1H-NMR-based metabonomic study on the anti-depressive effect of the total alkaloid of Corydalis Rhizoma |
Overall design | In this study, the anti-depressive effect of the total alkaloid of YuanHu (YHTA) was investigated in a chronic unpredictable mild stress (CUMS) rat model using 1H-NMR-based metabonomics. Plasma metabolic profiles were analyzed and multivariate data analysis was applied to discover the metabolic biomarkers in CUMS rats. Rats were divided into 6 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + high dose of YHTA group (stress plus YHTA treatment at the dose of 12 mg/kg), (4) CUMS + middle dose of YHTA group (stress plus YHTA treatment at the dose of 6 mg/kg), (5) CUMS + low dose of YHTA group (stress plus YHTA treatment at the dose of 3 mg/kg), and (6) CUMS + venlafaxine group (stress plus venlafaxine treatment at the dose of 8 mg/kg). The CUMS stress procedure lasted for 3 weeks, and drugs were intragastrically administered during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 48 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Varian Unity INOVA 600 NMR spectrometer; |
PMID | |
DOI | |
Citation | Wu H, Wang P, Liu M, et al. A 1H-NMR-based metabonomic study on the anti-depressive effect of the total alkaloid of Corydalis Rhizoma. Molecules 2015;20(6):10047-64. |
Metabolite | myo-Inositol; Citric acid; Glycerol; 3-Hydroxybutyric acid; L-Phenylalanine; L-Valine; L-Leucine; L-Glutamic acid; Glycine; L-Threonine; L-Methionine; L-Lactic acid; L-Glutamine; L-Lysine; N-acetyl glycoprotein; Pyruvic acid; Creatine; Beta-D-Glucose; L-Histidine; LDL; VLDL; alpha-D-Glucose; Acetoacetic acid; unsaturated lipids L17; |
